The role of beta-lactamase-producing-bacteria in mixed infections

Beta-lactamase-producing bacteria (BLPB) can play an important role in polymicrobial infections. They can have a direct pathogenic impact in causing the infection as well as an indirect effect through their ability to produce the enzyme beta-lactamase. BLPB may not only survive penicillin therapy but can also, as was demonstrated in in vitro and in vivo studies, protect other penicillin-susceptible bacteria from penicillin by releasing the free enzyme into their environment. This phenomenon occurs in upper respiratory tract, skin, soft tissue, surgical and other infections. The clinical, in vitro, and in vivo evidence supporting the role of these organisms in the increased failure rate of penicillin in eradication of these infections and the implication of that increased rate on the management of infections is discussed

The Stellar Halo Metallicity - Luminosity Relationship for Spiral Galaxies

The stellar halos of spiral galaxies bear important chemo-dynamical signatures of galaxy formation. We present here the analysis of 89 semi-cosmological spiral galaxy simulations, spanning ~ 4 magnitudes in total galactic luminosity. These simulations sample a wide variety of merging histories and show significant dispersion in halo metallicity at a given total luminosity - more than a factor of ten in metallicity. Our preliminary analysis suggests that galaxies with a more extended merging history possess halos which have younger and more metal rich stellar populations than the stellar halos associated with galaxies with a more abbreviated assembly. A correlation between halo metallicity and its surface brightness has also been found, reflecting the correlation between halo metallicity and its stellar mass. Our simulations are compared with recent Hubble Space Telescope observations of resolved stellar halos in nearby spirals.Comment: 5 pages, 4 figures. MNRAS Letters, in pres

Intervention Mapping: Physical Activity with Socially Disadvantaged Women - ePoster

Introduction Socially disadvantaged women (SDW) have lower levels of physical activity (PA), health inequalities and poorer health outcomes. These are associated with social determinants of health, e.g. Socioeconomic position and ethnic minority. Developing effective behaviour change programmes for SDW is complex due to disparities such as limited income and/or culturally inappropriate settings. These intricacies are often overlooked in PA policy. Consequently, interventions aimed at SDW often fail to show adequate reach, adoption and/or maintenance of PA. Therefore, we aim to inform policy and practice by developing needs-led PA interventions with SDW using Intervention Mapping (IM). IM begins with a needs assessment and follows an iterative six step process for planning interventions. Method Needs assessment tasks involved regular researcher participation in local PA sessions with SDW. The researcher also conducted 17 semi-structured interviews with SDW and community PA practitioners on the topic of PA. This data was thematically analysed and used within the first step of IM: to create a logic model of the PA health problem. Results Data gathered from interviews shows PA variety and suitable opportunities in Leeds and surrounding areas are lacking for SDW. These insights have demonstrated that the needs of SDW are essential to inform IM, PA policy and practice. Conclusion IM begins with a needs-led approach when tackling the health problem of inactivity for SDW. IM will continue to be used to design a comprehensive tool for practice and inform PA policy for SDW

Impacts of a flaring star-forming disc and stellar radial mixing on the vertical metallicity gradient

Using idealized N-body simulations of a Milky Way-sized disc galaxy, we qualitatively study how the metallicity distributions of the thin disc star particles are modified by the formation of the bar and spiral arm structures. The thin disc in our numerical experiments initially has a tight negative radial metallicity gradient and a constant vertical scaleheight. We show that the radial mixing of stars drives a positive vertical metallicity gradient in the thin disc. On the other hand, if the initial thin disc is flared, with vertical scaleheight increasing with galactocentric radius, the metal-poor stars, originally in the outer disc, become dominant in regions above the disc plane at every radii. This process can drive a negative vertical metallicity gradient, which is consistent with the current observed trend. This model mimics a scenario where the star-forming thin disc was flared in the outer region at earlier epochs. Our numerical experiment with an initial flared disc predicts that the negative vertical metallicity gradient of the mono-age relatively young thin disc population should be steeper in the inner disc, and the radial metallicity gradient of the mono-age population should be shallower at greater heights above the disc plane. We also predict that the metallicity distribution function of mono-age young thin disc populations above the disc plane would be more positively skewed in the inner disc compared to the outer disc

The role of feedback in shaping the structure of the interstellar medium

We present an analysis of the role of feedback in shaping the neutral hydrogen (H I) content of simulated disc galaxies. For our analysis, we have used two realizations of two separate Milky Way-like (similar to L star) discs - one employing a conservative feedback scheme (McMaster Unbiased Galaxy Survey), the other significantly more energetic [Making Galaxies In a Cosmological Context (MaGICC)]. To quantify the impact of these schemes, we generate zeroth moment (surface density) maps of the inferred H I distribution; construct power spectra associated with the underlying structure of the simulated cold interstellar medium, in addition to their radial surface density and velocity dispersion profiles. Our results are compared with a parallel, self-consistent, analysis of empirical data from The H I Nearby Galaxy Survey (THINGS). Single power-law fits (P proportional to k(gamma)) to the power spectra of the stronger feedback (MaGICC) runs (over spatial scales corresponding to similar to 0.5 to similar to 20 kpc) result in slopes consistent with those seen in the THINGS sample (gamma similar to -2.5). The weaker feedback (MUGS) runs exhibit shallower power-law slopes (gamma similar to -1.2). The power spectra of the MaGICC simulations are more consistent though with a two-component fit, with a flatter distribution of power on larger scales (i.e. gamma similar to -1.4 for scales in excess of similar to 2 kpc) and a steeper slope on scales below similar to 1 kpc (gamma similar to -5), qualitatively consistent with empirical claims, as well as our earlier work on dwarf discs. The radial H I surface density profiles of the MaGICC discs show a clear exponential behaviour, while those of the MUGS suite are essentially flat; both behaviours are encountered in nature, although the THINGS sample is more consistent with our stronger (MaGICC) feedback runs

Carbon cycle dynamics during episodes of rapid climate change

Past climate records reveal many instances of rapid climate change that are often coincident with fast changes in atmospheric greenhouse gas concentrations, suggesting links and positive feedbacks between the carbon cycle and the physical climate system. The carbon reservoirs that might have played an important role during these past episodes of rapid change include near-surface soil and peatland carbon, permafrost, carbon stored in vegetation, methane hydrates in deep-sea sediments, volcanism, and carbon stored in parts of the ocean that are easily ventilated through changes in circulation. To determine whether similar changes might lie in store in our future, we must gain a better understanding of the physics, biogeochemistry, dynamics, and feedbacks involved in such events. Specifically, we need to ascertain the main natural sources of atmospheric carbon dioxide and methane linked to rapid climate events in the paleoclimate record, and understand the mechanisms, triggers, thresholds, and feedbacks that were involved. Our review contributes to this focus issue by synthesizing results from nine studies covering a broad range of past time episodes. Studies are categorized into (a) episodes of massive carbon release millions of years ago; (b) the transition from the last glacial to the current interglacial 19 000–11 000 years ago; and (c) the current era. We conclude with a discussion on major remaining research challenges and implications for future projections and risk assessment.Publisher PDFPeer reviewe

MaGICC baryon cycle: the enrichment history of simulated disc galaxies

Using cosmological galaxy formation simulations from the MaGICC (Making Galaxies in a Cosmological Context) project, spanning stellar mass from ∼107 to 3 × 1010 M⊙, we trace the baryonic cycle of infalling gas from the virial radius through to its eventual participation in the star formation process. An emphasis is placed upon the temporal history of chemical enrichment during its passage through the corona and circumgalactic medium. We derive the distributions of time between gas crossing the virial radius and being accreted to the star-forming region (which allows for mixing within the corona), as well as the time between gas being accreted to the star-forming region and then ultimately forming stars (which allows for mixing within the disc). Significant numbers of stars are formed from gas that cycles back through the hot halo after first accreting to the star-forming region. Gas entering high-mass galaxies is pre-enriched in low-mass proto-galaxies prior to entering the virial radius of the central progenitor, with only small amounts of primordial gas accreted, even at high redshift (z ∼ 5). After entering the virial radius, significant further enrichment occurs prior to the accretion of the gas to the star-forming region, with gas that is feeding the star-forming region surpassing 0.1 Z⊙ by z = 0. Mixing with halo gas, itself enriched via galactic fountains, is thus crucial in determining the metallicity at which gas is accreted to the disc. The lowest mass simulated galaxy (Mvir ∼ 2 × 1010 M⊙, with M⋆ ∼ 107 M⊙), by contrast, accretes primordial gas through the virial radius and on to the disc, throughout its history. Much like the case for classical analytical solutions to the so-called ‘G-dwarf problem’, overproduction of low-metallicity stars is ameliorated by the interplay between the time of accretion on to the disc and the subsequent involvement in star formation – i.e. due to the inefficiency of star formation. Finally, gas outflow/metal removal rates from star-forming regions as a function of galactic mass are presented

Momentum Spectra in the Current Region of the Breit Frame in Deep Inelastic Scattering at HERA

The production of charged particles has been measured in deep inelastic scattering (DIS) with the ZEUS detector. The evolution of the moments of the scaled momenta distributions in $Q^2$ and $x$ has been investigated in the current fragmentation region of the Breit frame. The results in the current region are compared to $e^+e^-$ data and QCD analytical calculations. The results are consistent with the universality of single-particle spectra in DIS and $e^+e^-$ annihilation at high $Q^2.$ The results at low $Q^2$ disagree with analytical calculations based on the modified leading log approximation (MLLA) and local parton hadron duality (LPHD).Comment: 3 pages. 1 postscript figure + 1 postscript preprint logo + 1 LaTeX file + 1 style fil

Development of Feeding Cues During Infancy and Toddlerhood

To enhance responsive feeding, this study aimed to characterize the development of feeding cues during infancy and toddlerhood